Role of Glutathione S-Transferase M1 and T1 Gene Polymorphisms in Adult Acute Myeloid Leukemia Susceptibility
نویسندگان
چکیده
Objectives: Authors aimed to investigate the association between GSTT1 and GSTM1 genetic polymorphism and susceptibility to acute myeloid leukemia (AML). Materials and methods: Genotyping polymorphisms were studied in a total adult 178 individuals (88 newly diagnosed AML patients and 90 healthy controls) using multiplex polymerase chain reaction (PCR). Results: Significant difference was reported between genotype polymorphism in AML as compared to control individuals. High risk incidence was detected when dual null of the candidate genotypes were combined (p < 0.0001). Conclusion: Dual combination of the null GSTT1 and GSTM1 were superior to the susceptibility to leukemogenesis.
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تاریخ انتشار 2017